25 Osane Lizarralde, Felix Larrinaga and Urtzi Markiegi. University-Business cooperation to enhance Innovation and Enterpreneurship using PBLs 71 Andrew L. Gerhart, Donald D. Carpenter and Robert W. Fletcher. Developing Design and Professional Skills through Project-based Learning focused on the Grand Challenges for Engineering 113 Juan Ignacio Igartua, Jaione Ganzarain and Nekane Errasti. A Collaborative Experience of the Industrial Area in an Academic Reality through the PBL Development 161 Rui M. Lima, Diana Mesquita, Rui M. Sousa and José Dinis-Carvalho. Promoting the Interaction with the Industry through Project-Based Learning 200 Amaia Gomendio, Mikel Ezkurra, Aitor Madariaga, Eider Fortea, Patxi Aristimuño. Combined Work and Study learning approach, a new model to achieve professional skills in Engineering Education